Serological evidence for avian H9N2 influenza virus infections among Romanian agriculture workers.
Identifieur interne : 000833 ( Main/Exploration ); précédent : 000832; suivant : 000834Serological evidence for avian H9N2 influenza virus infections among Romanian agriculture workers.
Auteurs : Alexandru Coman [Roumanie] ; Daniel N. Maftei ; Whitney S. Krueger ; Gary L. Heil ; John A. Friary ; Razvan M. Chereches ; Emanuela Sirlincan ; Paul Bria ; Claudiu Dragnea ; Iosif Kasler ; Gregory C. GraySource :
- Journal of infection and public health [ 1876-035X ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Agriculture, Animaux, Anticorps antiviraux (sang), Exposition professionnelle, Femelle, Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Mâle, Roumanie (épidémiologie), Sous-type H9N2 du virus de la grippe A (immunologie), Tests de neutralisation, Zoonoses (virologie), Zoonoses (épidémiologie), Études séroépidémiologiques.
- MESH :
- immunologie : Sous-type H9N2 du virus de la grippe A.
- sang : Anticorps antiviraux.
- virologie : Grippe humaine, Zoonoses.
- épidémiologie : Grippe humaine, Roumanie, Zoonoses.
- Adulte, Adulte d'âge moyen, Agriculture, Animaux, Exposition professionnelle, Femelle, Humains, Mâle, Tests de neutralisation, Études séroépidémiologiques.
- Wicri :
- geographic : Roumanie.
English descriptors
- KwdEn :
- Adult, Agriculture, Animals, Antibodies, Viral (blood), Female, Humans, Influenza A Virus, H9N2 Subtype (immunology), Influenza, Human (epidemiology), Influenza, Human (virology), Male, Middle Aged, Neutralization Tests, Occupational Exposure, Romania (epidemiology), Seroepidemiologic Studies, Zoonoses (epidemiology), Zoonoses (virology).
- MESH :
- chemical , blood : Antibodies, Viral.
- geographic , epidemiology : Romania.
- epidemiology : Influenza, Human, Zoonoses.
- immunology : Influenza A Virus, H9N2 Subtype.
- virology : Influenza, Human, Zoonoses.
- Adult, Agriculture, Animals, Female, Humans, Male, Middle Aged, Neutralization Tests, Occupational Exposure, Seroepidemiologic Studies.
Abstract
In recent years, wild birds have introduced multiple highly pathogenic avian influenza (HPAI) H5N1 virus infections in Romanian poultry. In 2005 HPAI infections were widespread among domestic poultry and anecdotal reports suggested domestic pigs may also have been exposed. We sought to examine evidence for zoonotic influenza infections among Romanian agriculture workers. Between 2009 and 2010, 363 adult participants were enrolled in a cross-sectional, seroepidemiological study. Confined animal feeding operation (CAFO) swine workers in Tulcea and small, traditional backyard farmers in Cluj-Napoca were enrolled, as well as a non-animal exposed control group from Cluj-Napoca. Enrollment sera were examined for serological evidence of previous infection with 9 avian and 3 human influenza virus strains. Serologic assays showed no evidence of previous infection with 7 low pathogenic avian influenza viruses or with HPAI H5N1. However, 33 participants (9.1%) had elevated microneutralization antibody titers against avian-like A/Hong Kong/1073/1999(H9N2), 5 with titers ≥ 1:80 whom all reported exposure to poultry. Moderate poultry exposure was significantly associated with elevated titers after controlling for the subjects' age (adjusted OR = 3.6; 95% CI, 1.1-12.1). There was no evidence that previous infection with human H3N2 or H2N2 viruses were confounding the H9N2 seroreactivity. These data suggest that H9N2 virus may have circulated in Romanian poultry and occasionally infected man.
DOI: 10.1016/j.jiph.2013.05.003
PubMed: 23999337
Affiliations:
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Chereches</name></author><author><name sortKey="Sirlincan, Emanuela" sort="Sirlincan, Emanuela" uniqKey="Sirlincan E" first="Emanuela" last="Sirlincan">Emanuela Sirlincan</name></author><author><name sortKey="Bria, Paul" sort="Bria, Paul" uniqKey="Bria P" first="Paul" last="Bria">Paul Bria</name></author><author><name sortKey="Dragnea, Claudiu" sort="Dragnea, Claudiu" uniqKey="Dragnea C" first="Claudiu" last="Dragnea">Claudiu Dragnea</name></author><author><name sortKey="Kasler, Iosif" sort="Kasler, Iosif" uniqKey="Kasler I" first="Iosif" last="Kasler">Iosif Kasler</name></author><author><name sortKey="Gray, Gregory C" sort="Gray, Gregory C" uniqKey="Gray G" first="Gregory C" last="Gray">Gregory C. Gray</name></author></analytic><series><title level="j">Journal of infection and public health</title><idno type="eISSN">1876-035X</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Agriculture</term><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Female</term><term>Humans</term><term>Influenza A Virus, H9N2 Subtype (immunology)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (virology)</term><term>Male</term><term>Middle Aged</term><term>Neutralization Tests</term><term>Occupational Exposure</term><term>Romania (epidemiology)</term><term>Seroepidemiologic Studies</term><term>Zoonoses (epidemiology)</term><term>Zoonoses (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Agriculture</term><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Exposition professionnelle</term><term>Femelle</term><term>Grippe humaine (virologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Mâle</term><term>Roumanie (épidémiologie)</term><term>Sous-type H9N2 du virus de la grippe A (immunologie)</term><term>Tests de neutralisation</term><term>Zoonoses (virologie)</term><term>Zoonoses (épidémiologie)</term><term>Études séroépidémiologiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Romania</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Sous-type H9N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H9N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term><term>Roumanie</term><term>Zoonoses</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Agriculture</term><term>Animals</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neutralization Tests</term><term>Occupational Exposure</term><term>Seroepidemiologic Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Agriculture</term><term>Animaux</term><term>Exposition professionnelle</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Tests de neutralisation</term><term>Études séroépidémiologiques</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Roumanie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In recent years, wild birds have introduced multiple highly pathogenic avian influenza (HPAI) H5N1 virus infections in Romanian poultry. In 2005 HPAI infections were widespread among domestic poultry and anecdotal reports suggested domestic pigs may also have been exposed. We sought to examine evidence for zoonotic influenza infections among Romanian agriculture workers. Between 2009 and 2010, 363 adult participants were enrolled in a cross-sectional, seroepidemiological study. Confined animal feeding operation (CAFO) swine workers in Tulcea and small, traditional backyard farmers in Cluj-Napoca were enrolled, as well as a non-animal exposed control group from Cluj-Napoca. Enrollment sera were examined for serological evidence of previous infection with 9 avian and 3 human influenza virus strains. Serologic assays showed no evidence of previous infection with 7 low pathogenic avian influenza viruses or with HPAI H5N1. However, 33 participants (9.1%) had elevated microneutralization antibody titers against avian-like A/Hong Kong/1073/1999(H9N2), 5 with titers ≥ 1:80 whom all reported exposure to poultry. Moderate poultry exposure was significantly associated with elevated titers after controlling for the subjects' age (adjusted OR = 3.6; 95% CI, 1.1-12.1). There was no evidence that previous infection with human H3N2 or H2N2 viruses were confounding the H9N2 seroreactivity. These data suggest that H9N2 virus may have circulated in Romanian poultry and occasionally infected man.</div></front></TEI><affiliations><list><country><li>Roumanie</li></country></list><tree><noCountry><name sortKey="Bria, Paul" sort="Bria, Paul" uniqKey="Bria P" first="Paul" last="Bria">Paul Bria</name><name sortKey="Chereches, Razvan M" sort="Chereches, Razvan M" uniqKey="Chereches R" first="Razvan M" last="Chereches">Razvan M. Chereches</name><name sortKey="Dragnea, Claudiu" sort="Dragnea, Claudiu" uniqKey="Dragnea C" first="Claudiu" last="Dragnea">Claudiu Dragnea</name><name sortKey="Friary, John A" sort="Friary, John A" uniqKey="Friary J" first="John A" last="Friary">John A. Friary</name><name sortKey="Gray, Gregory C" sort="Gray, Gregory C" uniqKey="Gray G" first="Gregory C" last="Gray">Gregory C. Gray</name><name sortKey="Heil, Gary L" sort="Heil, Gary L" uniqKey="Heil G" first="Gary L" last="Heil">Gary L. Heil</name><name sortKey="Kasler, Iosif" sort="Kasler, Iosif" uniqKey="Kasler I" first="Iosif" last="Kasler">Iosif Kasler</name><name sortKey="Krueger, Whitney S" sort="Krueger, Whitney S" uniqKey="Krueger W" first="Whitney S" last="Krueger">Whitney S. Krueger</name><name sortKey="Maftei, Daniel N" sort="Maftei, Daniel N" uniqKey="Maftei D" first="Daniel N" last="Maftei">Daniel N. Maftei</name><name sortKey="Sirlincan, Emanuela" sort="Sirlincan, Emanuela" uniqKey="Sirlincan E" first="Emanuela" last="Sirlincan">Emanuela Sirlincan</name></noCountry><country name="Roumanie"><noRegion><name sortKey="Coman, Alexandru" sort="Coman, Alexandru" uniqKey="Coman A" first="Alexandru" last="Coman">Alexandru Coman</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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